Synthesis of 1,3-diols by O-nucleophile additions to activated alkenes

Gamba-Sanchez, D. and Prunet, J. (2018) Synthesis of 1,3-diols by O-nucleophile additions to activated alkenes. Synthesis, 50(20), pp. 3997-4007. (doi: 10.1055/s-0037-1610248)

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The diastereoselective synthesis of 1,3-diols by addition of oxygen nucleophiles to activated alkenes is presented. This review focuses on homoallylic alcohol substrates that react with a relay compound to form an intermediate oxygen nucleophile, which in turn will lead to a protected 1,3-diol by intramolecular addition to the olefin moiety.

Item Type:Articles
Additional Information:Financial support was provided by Fondo de Investigaciones de la Facultad de Ciencias de la Universidad de los Andes, convocatoria 2018-2019 para la Financiación de Programas de Investigación “use of threonine as chiral auxiliary”
Glasgow Author(s) Enlighten ID:Prunet, Dr Joelle
Authors: Gamba-Sanchez, D., and Prunet, J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Synthesis
Publisher:Georg Thieme Verlag
ISSN (Online):1437-210X
Published Online:30 August 2018
Copyright Holders:Copyright © 2018 Georg Thieme Verlag
First Published:First published in Synthesis 50(20): 3997-4007
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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