Mesocosm experiments reveal the impact of mosquito control measures on malaria vector life history and population dynamics

Ng'habi, K., Viana, M. , Matthiopoulos, J. , Lyimo, I., Killeen, G. and Ferguson, H. M. (2018) Mesocosm experiments reveal the impact of mosquito control measures on malaria vector life history and population dynamics. Scientific Reports, 8, 13949. (doi:10.1038/s41598-018-31805-8) (PMID:30224714) (PMCID:PMC6141522)

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Abstract

The impact of control measures on mosquito vector fitness and demography is usually estimated from bioassays or indirect variables in the field. Whilst indicative, neither approach is sufficient to quantify the potentially complex response of mosquito populations to combined interventions. Here, large replicated mesocosms were used to measure the population-level response of the malaria vector Anopheles arabiensis to long-lasting insecticidal nets (LLINs) when used in isolation, or combined with insecticidal eave louvers (EL), or treatment of cattle with the endectocide Ivermectin (IM). State-space models (SSM) were fit to these experimental data, revealing that LLIN introduction reduced adult mosquito survival by 91% but allowed population persistence. ELs provided no additional benefit, but IM reduced mosquito fecundity by 59% and nearly eliminated all populations when combined with LLINs. This highlights the value of IM for integrated vector control, and mesocosm population experiments combined with SSM for identifying optimal combinations for vector population elimination.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Matthiopoulos, Professor Jason and Viana, Dr Mafalda and Ferguson, Professor Heather
Authors: Ng'habi, K., Viana, M., Matthiopoulos, J., Lyimo, I., Killeen, G., and Ferguson, H. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Scientific Reports 8:13949
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
425321A systems biology approach to infectious disease transmission - linking individuals, populations and ecosystemsHeather FergusonBiotechnology and Biological Sciences Research Council (BBSRC)BB/D020042/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED
709181Ecology of insecticide resistant vectors: consequences for the effectiveness of malaria control strategiesMafalda VianaMedical Research Council (MRC)MR/N015320/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED