Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort

Welsh, P. et al. (2018) Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort. Clinical Chemistry, 64(11), pp. 1607-1616. (doi:10.1373/clinchem.2018.292086) (PMID:30126950)

[img] Text
167693.pdf - Accepted Version
Restricted to Repository staff only until 20 August 2019.

1MB

Abstract

Background: Few data compare cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in a general population. We sought to evaluate the distribution and association between cTnT, cTnI, and cardiovascular risk factors in a large general population cohort. Methods: High-sensitivity cTnT and cTnI were measured in serum from 19501 individuals in the Generation Scotland Scottish Family Health Study. Associations with cardiovascular risk factors were compared using age- and sex-adjusted regression. Observed age- and sex-stratified 99th centiles were compared with 99th centiles for cTnT (men, 15.5 ng/L; women, 9.0 ng/L) and cTnI (men, 34.2 ng/L; women, 15.6 ng/L) used in clinical practice. Results: cTnT and cTnI concentrations were detectable in 53.3% and 74.8% of participants, respectively, and were modestly correlated in unadjusted analyses (R2 = 21.3%) and only weakly correlated after adjusting for age and sex (R2 = 9.5%). Cardiovascular risk factors were associated with both troponins, but in age- and sex-adjusted analyses, cTnI was more strongly associated with age, male sex, body mass index, and systolic blood pressure (P < 0.0001 for all vs cTnT). cTnT was more strongly associated with diabetes (P < 0.0001 vs cTnI). The observed 99th centiles were broadly consistent with recommended 99th centiles in younger men and women. After the age of 60 years, observed 99th centiles increased substantially for cTnT, and beyond 70 years of age, the 99th centiles approximately doubled for both troponins. Conclusions: In the general population, cTnT and cTnI concentrations are weakly correlated and are differentially associated with cardiovascular risk factors. The 99th centiles currently in use are broadly appropriate for men and women up to but not beyond the age of 60 years.

Item Type:Articles (Other)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preiss, Dr David and McConnachie, Dr Alex and Boachie, Mr Charles and Padmanabhan, Professor Sandosh and Welsh, Dr Paul and Briggs, Professor Andrew and Woodward, Professor Mark and McAllister, Dr David and Sattar, Professor Naveed and Welsh, Dr Claire
Authors: Welsh, P., Preiss, D., Shah, A. S.V., McAllister, D., Briggs, A., Boachie, C., McConnachie, A., Hayward, C., Padmanabhan, S., Welsh, C., Woodward, M., Campbell, A., Porteous, D., Mills, N. L., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Clinical Chemistry
Publisher:American Association for Clinical Chemistry
ISSN:0009-9147
ISSN (Online):1530-8561
Published Online:20 August 2018
Copyright Holders:Copyright © 2018 American Association for Clinical Chemistry
First Published:First published in Clinical Chemistry 64(11): 1607-1611
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
680921Cardiac biomarkers and the prediction of CVD in ScotlandPaul WelshChief Scientist office (CSO)ASM/14/1RI CARDIOVASCULAR & MEDICAL SCIENCES
381721Generation ScotlandAnna DominiczakChief Scientist office (CSO)CZD/16/6RI CARDIOVASCULAR & MEDICAL SCIENCES