Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA

Selby, N. M. et al. (2018) Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Nephrology Dialysis Transplantation, 33(suppl2), ii4-ii14. (doi: 10.1093/ndt/gfy152) (PMID:30137584)

Abstract

Functional renal magnetic resonance imaging (MRI) has seen a number of recent advances, and techniques are now available that can generate quantitative imaging biomarkers with the potential to improve the management of kidney disease. Such biomarkers are sensitive to changes in renal blood flow, tissue perfusion, oxygenation and microstructure (including inflammation and fibrosis), processes that are important in a range of renal diseases including chronic kidney disease. However, several challenges remain to move these techniques towards clinical adoption, from technical validation through biological and clinical validation, to demonstration of cost-effectiveness and regulatory qualification. To address these challenges, the European Cooperation in Science and Technology Action PARENCHIMA was initiated in early 2017. PARENCHIMA is a multidisciplinary pan-European network with an overarching aim of eliminating the main barriers to the broader evaluation, commercial exploitation and clinical use of renal MRI biomarkers. This position paper lays out PARENCHIMA’s vision on key clinical questions that MRI must address to become more widely used in patients with kidney disease, first within research settings and ultimately in clinical practice. We then present a series of practical recommendations to accelerate the study and translation of these techniques.

• Item Type: Articles
• Additional Information: P.B. is supported by the Deutsche Forschungsgemeinschaft (DFG; BO 3755/6-1, SFB/TRR57, SFB/TRR219) and by the German Ministry of Education and Research (BMBF Consortium STOP-FSGS number 01GM1518A). Alberto Ortiz is supported by Instituto de Salud Carlos III (PI16/ 2057, RETIC REDINREN RD16/0009), FEDER funds and Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. Aghogho Odudu is supported by an Academy of Medical Sciences starter grant (SGL015/1019) and National Insitute for Health Research Lectureship (CL-2014-06-003). S.S. is partly funded by the BEAt-DKD project through the IMI 2 JU under grant agreement 115974 (www.beat-dkd.eu). J.P.V. and H.C.T. are partially supported by Swiss National Foundation grants FNS 32003B_159714/1 (ME10250) and IZCOZ0_177140/1. M.W. is supported by the Austrian Science Fund (FWF) project P28867.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mark, Professor Patrick
• Authors: Selby, N. M., Blankestijn, P. J., Boor, P., Combe, C., Eckardt, K.-U., Eikefjord, E., Garcia-Fernandez, N., Golay, X., Gordon, I., Grenier, N., Hockings, P. D., Jensen, J. D., Joles, J. A., Kalra, P. A., Krämer, B. K., Mark, P. B., Mendichovszky, I. A., Nikolic, O., Odudu, A., Ong, A. C.M., Ortiz, A., Pruijm, M., Remuzzi, G., Rørvik, J., de Seigneux, S., Simms, R. J., Slatinska, J., Summers, P., Taal, M. W., Thoeny, H. C., Vallée, J.-P., Wolf, M., Caroli, A., and Sourbron, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Nephrology Dialysis Transplantation
• Publisher: Oxford University Press
• ISSN: 0931-0509
• ISSN (Online): 1460-2385
• Published Online: 23 August 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Nephrology Dialysis Transplantation 33(suppl2):ii4-ii14
• Publisher Policy: Reproduced under a Creative Commons License