Comparative developmental biology of the cardiac inflow tract

Carmona, R., Ariza, L., Cañete, A. and Muñoz-Chápuli, R. (2018) Comparative developmental biology of the cardiac inflow tract. Journal of Molecular and Cellular Cardiology, 116, pp. 155-164. (doi:10.1016/j.yjmcc.2018.02.004) (PMID:29452155)

Carmona, R., Ariza, L., Cañete, A. and Muñoz-Chápuli, R. (2018) Comparative developmental biology of the cardiac inflow tract. Journal of Molecular and Cellular Cardiology, 116, pp. 155-164. (doi:10.1016/j.yjmcc.2018.02.004) (PMID:29452155)

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Abstract

The vertebrate heart receives the blood through the cardiac inflow tract. This area has experienced profound changes along the evolution of vertebrates; changes that have a reflection in the cardiac ontogeny. The development of the inflow tract involves dynamic changes due to the progressive addition of tissue derived from the secondary heart field. The inflow tract is the site where oxygenated blood coming from lungs is received separately from the systemic return, where the cardiac pacemaker is established and where the proepicardium develops. Differential cell migration towards the inflow tract breaks the symmetry of the primary heart tube and determines the direction of the cardiac looping. In air-breathing vertebrates, an inflow tract reorganization is essential to keep separate blood flows from systemic and pulmonary returns. Finally, the sinus venosus endocardium has recently been recognized as playing a role in the constitution of the coronary vasculature. Due to this developmental complexity, congenital anomalies of the inflow tract can cause severe cardiac diseases. We aimed to review the recent literature on the cellular and molecular mechanisms that regulate the morphogenesis of the cardiac inflow tract, together with comparative and evolutionary details, thus providing a basis for a better understanding of these mechanisms.

Item Type:Articles
Additional Information:This work was supported by the Spanish Ministry of Economy and Competitiveness under Grant BFU2014-52299-P and Instituto de Salud Carlos III-TERCEL network under Grant RD12/0019-0022.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Canete Sanchez, Mrs Ana Elodia
Authors: Carmona, R., Ariza, L., Cañete, A., and Muñoz-Chápuli, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Molecular and Cellular Cardiology
Publisher:Elsevier
ISSN:0022-2828
ISSN (Online):1095-8584
Published Online:13 February 2018
Copyright Holders:Copyright © 2018 Elsevier Ltd.
First Published:First published in Journal of Molecular and Cellular Cardiology 116: 155-164
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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