Maruyma, K., Mizushina, S., Sugiura, T., Van Leeuwen, G.M.J., Hand, J.W., Marrocco, G., Bardati, F., Edwards, A.D., Azzopardi, D., and Land, D. (2000) Feasibility of noninvasive measurement of deep brain temperature in newborn infants by multifrequency microwave radiometry. IEEE Transactions on Microwave Theory and Techniques, 48 (11.2). 2141 -2147. ISSN 0018-9480 (doi:10.1109/22.884206)
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Publisher's URL: http://dx.doi.org/10.1109/22.884206
Clinical studies of hypothermal neural rescue therapy for newborn infants who have suffered hypoxia-ischaemia are currently hindered by the difficulty in measuring deep brain temperature. This paper addresses: the specific requirements for this measurement problem, the design of a proposed radiometer system, a method for retrieving the temperature profile within the cooled head, and an estimation of the precision of the measurement of deep brain temperature using the technique. A five-frequency-band radiometer with a contact-type antenna operating within the range 1-4 GHz is proposed to obtain brightness temperatures corresponding to temperature profiles predicted by a realistic thermal model of the cooled baby head. The problems of retrieving the temperature profile from this set of brightness temperatures, and the estimation of its precision, are solved using a combination of model fitting and Monte Carlo techniques. The results of this paper show that the proposed technique is feasible, that it is expected to provide a good estimate of the temperature profile within the cooled baby-head, and that the estimated precision (2σ) of the temperature measured in the deep brain structures is better than 0.8 K, depending upon the estimation procedure used.
|Glasgow Author(s):||Land, Dr David|
|Authors:||Maruyma, K., Mizushina, S., Sugiura, T., Van Leeuwen, G.M.J., Hand, J.W., Marrocco, G., Bardati, F., Edwards, A.D., Azzopardi, D., and Land, D.|
|Subjects:||Q Science > QC Physics|
R Medicine > RJ Pediatrics
Q Science > QP Physiology
|College/School:||College of Science and Engineering > School of Physics and Astronomy|
|Journal Name:||IEEE Transactions on Microwave Theory and Techniques|