Extracellular vesicles, ageing, and therapeutic interventions

Panagiotou, N. , Neytchev, O. , Selman, C. and Shiels, P. G. (2018) Extracellular vesicles, ageing, and therapeutic interventions. Cells, 7(8), 110. (doi:10.3390/cells7080110) (PMID:30126173) (PMCID:PMC6115766)

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Abstract

A more comprehensive understanding of the human ageing process is required to help mitigate the increasing burden of age-related morbidities in a rapidly growing global demographic of elderly individuals. One exciting novel strategy that has emerged to intervene involves the use of extracellular vesicles to engender tissue regeneration. Specifically, this employs their molecular payloads to confer changes in the epigenetic landscape of ageing cells and ameliorate the loss of functional capacity. Understanding the biology of extracellular vesicles and the specific roles they play during normative ageing will allow for the development of novel cell-free therapeutic interventions. Hence, the purpose of this review is to summarise the current understanding of the mechanisms that drive ageing, critically explore how extracellular vesicles affect ageing processes and discuss their therapeutic potential to mitigate the effects of age-associated morbidities and improve the human health span.

Item Type:Articles
Additional Information:N.P. was funded by a studentship award from the Biotechnology and Biological Sciences Research Council (BBSRC) to P.G.S. and C.S. O.N. was funded by an IPP from UoG (University of Glasgow) and Constant Pharma Ltd. award to P.G.S. and C.S.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Neytchev, Ognian and Selman, Professor Colin and Panagiotou, Nikolaos and Shiels, Professor Paul
Authors: Panagiotou, N., Neytchev, O., Selman, C., and Shiels, P. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cells
Publisher:MDPI
ISSN:2073-4409
ISSN (Online):2073-4409
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Cells 7(8):110
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
500151Doctoral Training Grant 2009-15Timothy PalmerBiotechnology and Biological Sciences Research Council (BBSRC)BB/F016735/1RI CARDIOVASCULAR & MEDICAL SCIENCES
5887510BBSRC Doctoral Training Partnership 2012George BaillieBiotechnology and Biological Sciences Research Council (BBSRC)BB/J013854/1MVLS COLLEGE SENIOR MANAGEMENT