Designing stem cell niches for differentiation and self-renewal

Donnelly, H., Salmeron-Sanchez, M. and Dalby, M. J. (2018) Designing stem cell niches for differentiation and self-renewal. Journal of the Royal Society: Interface, 15(145), 20180388. (doi:10.1098/rsif.2018.0388) (PMID:30158185) (PMCID:PMC6127175)

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Abstract

Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in contact with their specialized microenvironment, termed the stem cell niche. Niches provide structural and functional cues that are both biochemical and biophysical, stem cells integrate this complex array of signals with intrinsic regulatory networks to meet physiological demands. Although, some of these regulatory mechanisms remain poorly understood or difficult to harness with traditional culture systems. Biomaterial strategies are being developed that aim to recapitulate stem cell niches, by engineering microenvironments with physiological-like niche properties that aim to elucidate stem cell-regulatory mechanisms, and to harness their regenerative capacity in vitro. In the future, engineered niches will prove important tools for both regenerative medicine and therapeutic discoveries.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and DONNELLY, HANNAH and Dalby, Professor Matthew
Authors: Donnelly, H., Salmeron-Sanchez, M., and Dalby, M. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Journal of the Royal Society: Interface
Publisher:The Royal Society
ISSN:1742-5689
ISSN (Online):1742-5662
Published Online:29 August 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of the Royal Society: Interface 15(145):20180388
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
653731Synergistic microenvironments for non-union bone defectsMatthew DalbyMedical Research Council (MRC)MR/L022710/1RI MOLECULAR CELL & SYSTEMS BIOLOGY
722061Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - BIOMEDICAL ENGINEERING
728381Rapid Bone Graft Synthesis Through Dual Piezoelectric/Nanomechaniocal StimulationMatthew DalbyBiotechnology and Biological Sciences Research Council (BBSRC)BB/P00220X/1RI MOLECULAR CELL & SYSTEMS BIOLOGY
717521Materials exploitation of the biointerface to control MSC quality and niche phenotypeMatthew DalbyBiotechnology and Biological Sciences Research Council (BBSRC)BB/N018419/1RI MOLECULAR CELL & SYSTEMS BIOLOGY