Relationships between maternal obesity and maternal and neonatal iron status.

Flynn, A. C. et al. (2018) Relationships between maternal obesity and maternal and neonatal iron status. Nutrients, 10(8), 1000. (doi:10.3390/nu10081000) (PMID:30061547)

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Abstract

Obesity in pregnancy may negatively influence maternal and infant iron status. The aim of this study was to examine the association of obesity with inflammatory and iron status in both mother and infant in two prospective studies in pregnancy: UPBEAT and SCOPE. Maternal blood samples from obese ( = 245, BMI ≥ 30 kg/m²) and normal weight ( = 245, BMI < 25 kg/m²) age matched pregnant women collected at approximately 15 weeks' gestation, and umbilical cord blood samples collected at delivery, were analysed for a range of inflammatory and iron status biomarkers. Concentrations of C- reactive protein and Interleukin-6 in obese women compared to normal weight women were indicative of an inflammatory response. Soluble transferrin receptor (sTfR) concentration [18.37 nmol/L (SD 5.65) vs 13.15 nmol/L (SD 2.33)] and the ratio of sTfR and serum ferritin [1.03 (SD 0.56) vs 0.69 (SD 0.23)] were significantly higher in obese women compared to normal weight women ( < 0.001). Women from ethnic minority groups ( = 64) had higher sTfR concentration compared with white women. There was no difference in maternal hepcidin between obese and normal weight women. Iron status determined by cord ferritin was not statistically different in neonates born to obese women compared with neonates born to normal weight women when adjusted for potential confounding variables. Obesity is negatively associated with markers of maternal iron status, with ethnic minority women having poorer iron statuses than white women.

Item Type:Articles
Additional Information:This research was funded by the Allen Foundation Inc., Michigan, US. UPBEAT was funded by the National Institute for Health Research (NIHR) (UK) under the Programme Grants for Applied Research Programme RP-0407-10452. The Irish SCOPE study was funded by the Health Research Board of Ireland (CSA/2007/2; http://www.hrb.ie). The Cork BASELINE Birth Cohort Study was funded by the National Children’s Research Centre, Dublin, Ireland.
Keywords:Inflammation, iron status, obesity, pregnancy
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nelson, Professor Scott
Authors: Flynn, A. C., Begum, S., White, S. L., Dalrymple, K., Gill, C., Alwan, N. A., Kiely, M., Latunde-Dada, G., Bell, R., Briley, A. L., Nelson, S. M., Oteng-Ntim, E., Sandall, J., Sanders, T. A., Whitworth, M., Murray, D. M., Kenny, L. C., Poston, L., and On Behalf Of The Scope And Upbeat Consortiums, O. B. O. T.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Nutrients
ISSN:2072-6643
ISSN (Online):2072-6643
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Nutrients 10:1000
Publisher Policy:Reproduced under a Creative Commons License

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