Secretory organelle trafficking in Toxoplasma gondii: a long story for a short travel

Venugopal, K. and Marion, S. (2018) Secretory organelle trafficking in Toxoplasma gondii: a long story for a short travel. International Journal of Medical Microbiology, 308(7), pp. 751-760. (doi: 10.1016/j.ijmm.2018.07.007) (PMID:30055977)

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Abstract

Toxoplasma gondii (T. gondii) possesses a highly polarized secretory system, which efficiently assembles de novo micronemes (MIC) and rhoptries (ROP) during parasite replication. Pioneer works have studied the sorting motifs within MIC and ROP proteins, required for their trafficking towards their final destination. These studies led to the conclusion that protein processing and protein sorting are inter-dependent activities. More recent works have revealed the trafficking routes taken by the MIC and ROP proteins by examining the functions of the endo-exocytic compartments and identified key molecules involved in protein sorting and transport. These recent findings have suggested that T. gondii has repurposed the evolutionarily conserved regulators of the endosomal system to the secretory pathway. This review reports the pioneer as well as the most recent findings on the molecular mechanisms regulating apical organelle and dense granule biogenesis and portrays the parasite as a remarkable secretory machine that has efficiently remodeled its trafficking system to adapt to an intracellular lifestyle.

Item Type:Articles
Keywords:Endo-exocytic compartments, protein processing, secretory system, trafficking.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Venugopal, Dr Kannan
Authors: Venugopal, K., and Marion, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of Medical Microbiology
Publisher:Elsevier
ISSN:1438-4221
ISSN (Online):1618-0607
Published Online:21 July 2018

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