Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment – a review of contemporary studies

Hietamies, T. M., Ostrowski, C., Pei, Z., Feng, L., McCabe, C., Work, L. M. and Quinn, T. J. (2018) Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment – a review of contemporary studies. Journal of Cerebral Blood Flow and Metabolism, 38(11), pp. 1872-1884. (doi:10.1177/0271678X18799858) (PMID:30203705)

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Abstract

Despite promising preclinical data, few novel stroke therapies have shown efficacy in man. Efforts to improve standards in conduct and reporting of preclinical research are ongoing. In clinical trials, inconsistency in outcome measures led to regulatory agencies and funders mandating use of a core set of functional outcomes. Our aim was to describe functional outcome measures in preclinical stroke and vascular cognitive impairment (VCI) studies. From 14 high impact journals (January 2005–December 2015 inclusive), 91,956 papers were screened with 1302 full texts analyzed for stroke (ischemic and hemorrhagic) and 56 for VCI studies. In total, 636 (49%) stroke and 37 (66%) VCI papers reported functional outcome measures. There were 74 different functional assessments reported in stroke and 20 in VCI studies. Neurological deficit scores (74%) and Morris water maze (60%) were most commonly used in stroke and VCI, respectively. However, inconsistencies in methods used to assess and score recovery were noted. Neurological and behavioural functional outcome measures are increasingly used in preclinical stroke or VCI studies; however, there is substantial variation in methods. A strict standardized outcome set may not be suitable for translational work, but greater consistency in choice, application and reporting of outcomes may improve the science.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hietamies, Miss Tuuli and Work, Dr Lorraine and Quinn, Dr Terry
Authors: Hietamies, T. M., Ostrowski, C., Pei, Z., Feng, L., McCabe, C., Work, L. M., and Quinn, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Cerebral Blood Flow and Metabolism
Publisher:SAGE Publications
ISSN:0271-678X
ISSN (Online):1559-7016
Published Online:11 September 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Cerebral Blood Flow and Metabolism 38(11): 1872-1884
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
712591Targeting mitochondrial stability as a new therapy for strokeLorraine WorkCunningham Trust (CUNNINGT)YL/JL/CU15007.0001RI CARDIOVASCULAR & MEDICAL SCIENCES
686211Joint Stroke Association/Chief Scientist Office Senior Clinical LectureshipTerence QuinnStroke Association (STROKEAS)TSA15LECT05RI CARDIOVASCULAR & MEDICAL SCIENCES