Tyrosine dephosphorylation underlies DHPG-induced LTD

Moult, P. R., Schnabel, R., Kilpatrick, I. C., Bashir, Z. I. and Collingridge, G. L. (2002) Tyrosine dephosphorylation underlies DHPG-induced LTD. Neuropharmacology, 43(2), pp. 175-180. (doi:10.1016/S0028-3908(02)00110-7) (PMID:12213271)

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Abstract

A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 μM lavendustin A or 30 μM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 μM phenyl–arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Moult, Dr Peter
Authors: Moult, P. R., Schnabel, R., Kilpatrick, I. C., Bashir, Z. I., and Collingridge, G. L.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Neuropharmacology
Publisher:Elsevier
ISSN:0028-3908
ISSN (Online):1873-7064
Published Online:28 August 2002

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