The suppression of DNA repair induced by PARP-1 inhibitors rucaparib and olaparib in combination with the radiopharmaceutical 131I-MIBG in noradrenaline transporter-expressing xenograft tumors

Nile, D. L., Rae, C. , Nixon, C., Gaze, M. N. and Mairs, R. J. (2018) The suppression of DNA repair induced by PARP-1 inhibitors rucaparib and olaparib in combination with the radiopharmaceutical 131I-MIBG in noradrenaline transporter-expressing xenograft tumors. Cancer Therapy and Oncology International Journal, 10(3), 555788. (doi: 10.19080/CTOIJ.2018.10.555788)

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Abstract

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Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mairs, Professor Robert and Nixon, Mr Colin and Nile, Dr Donna and Rae, Dr Colin
Authors: Nile, D. L., Rae, C., Nixon, C., Gaze, M. N., and Mairs, R. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cancer Therapy and Oncology International Journal
Publisher:Juniper Publishers
ISSN:2473-554X
Copyright Holders:Copyright © 2018 Donna Nile
First Published:First published in Cancer Therapy and Oncology 10(3):555788
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
594601Assessment of [131l] MIBG in combination with cytotoxic drugs for neuroblastoma therapy.Robert MairsGreat Ormond Street Hospital For Children NHS Trust (NHS-GOSH)2012-NAT-04/W1057ICS - EPIGENETICS
691111Exploitation of the elevated metabolic activity of cancer cells for combination with targeted radiotherapy of neuroblastomaRobert MairsChildren with Cancer UK (CHILDCAN)15-191ICS - EPIGENETICS
735611Pre-clinical evaluation of PARP-1 inhibitors in combination with the radiopharmaceutical 131I-MIBG for the treatment of neuroblastomaRobert MairsGlasgow Children's Hospital Charity (GCHC)YRSS/SPG/2015/01ICS - EPIGENETICS
743801Targeted radiotherapy of prostate cancer with drugs exploiting the aberrant metabolism of tumoursRobert MairsChief Scientist office (CSO)TCS/16/38ICS - EPIGENETICS