The role of pro-inflammatory cytokines in inflammatory bowel disease growth retardation

Wong, S.C. , Macrae, V.E., McGrogan, P. and Ahmed, S.F. (2006) The role of pro-inflammatory cytokines in inflammatory bowel disease growth retardation. Journal of Pediatric Gastroenterology and Nutrition, 43(2), pp. 144-155. (doi: 10.1097/01.mpg.0000226374.18494.14) (PMID:16877976)

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Childhood inflammatory bowel disease (IBD) especially those with Crohn disease is commonly complicated by faltering growth and pubertal delay. Pro-inflammatory cytokines are often elevated in IBD and may affect linear growth and puberty either systemically or at the level of the growth plate. Further study of the underlying mechanisms of the deleterious effects of cytokines on the growth plate may improve management of faltering growth in childhood IBD. Well-controlled clinical studies of the respective effect of nutritional support, immunomodulatory therapy, biological agents and growth and puberty promoting agents on managing faltering growth also require further attention.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Wong, Dr Jarod and Ahmed, Professor Syed Faisal
Authors: Wong, S.C., Macrae, V.E., McGrogan, P., and Ahmed, S.F.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Journal of Pediatric Gastroenterology and Nutrition
Journal Abbr.:J Pediatr Gastroenterol Nutr
Publisher:Lippincott, Williams & Wilkins
ISSN (Online):1536-4801

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