Revisiting key entry routes of human epidemic arboviruses into the mainland Americas through large-scale phylogenomics

Campos, T. D. L., Durães-Carvalho, R., Rezende, A. M., de Carvalho, O. V., Kohl, A. , Wallau, G. L. and Pena, L. J. (2018) Revisiting key entry routes of human epidemic arboviruses into the mainland Americas through large-scale phylogenomics. International Journal of Genomics, 2018, 6941735. (doi:10.1155/2018/6941735)

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Abstract

The rapid worldwide spread of chikungunya (CHIKV), dengue (DENV) and Zika (ZIKV) viruses have raised great international concern. Knowledge about the entry routes and geographic expansion of these arboviruses to the mainland Americas remain incomplete and controversial. Epidemics caused by arboviruses continue to cause socioeconomic burden globally, particularly in countries where vector control is difficult due to climatic or infrastructure factors. Understanding how the virus circulates and moves from one country to another is of paramount importance to assist government and health officials in anticipating future epidemics, as well as to take steps to help control or mitigate the spread of the virus. Through the analyses of the sequences of arbovirus genomes collected at different locations over time, we identified patterns of accumulated mutations, being able to trace routes of dispersion of these viruses. Here, we applied robust phylogenomic methods to trace the evolutionary dynamics of these arboviruses with special focus on Brazil, the epicenter of these triple epidemics. Our results show that CHIKV, DENV-1-4 and ZIKV followed a similar path prior to their first introductions into the mainland Americas, underscoring the need for systematic arboviral surveillance at major entry points of human population movement between countries such as airports and seaports.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kohl, Professor Alain
Authors: Campos, T. D. L., Durães-Carvalho, R., Rezende, A. M., de Carvalho, O. V., Kohl, A., Wallau, G. L., and Pena, L. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of Genomics
Publisher:Hindawi
ISSN:2314-436X
ISSN (Online):2314-4378
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in International Journal of Genomics 2018:6941735
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
708681The emergence of Zika virus in Brazil: investigating prevalence and host responses to design preventive strategiesAlain KohlMedical Research Council (MRC)MR/N017552/1MVLS III - CENTRE FOR VIRUS RESEARCH
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH