Building kidney exchange programmes in Europe - an overview of exchange practice and activities

Biró, P. et al. (2019) Building kidney exchange programmes in Europe - an overview of exchange practice and activities. Transplantation, 103(7), pp. 1514-1522. (doi: 10.1097/TP.0000000000002432) (PMID:30247314) (PMCID:PMC6613834)

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Background: Considerable differences exist among the living donor Kidney Exchange Programmes (KEPs) that are in use and being built in Europe, contributing to a variation in the number of living donor transplants [6]. Efforts of European KEPs to exchange (best) practices and share approaches to address challenges have, however, been limited. Methods: Experts from 23 European countries, collaborating on the ENCKEP COST Action, developed a questionnaire to collect detailed information on the functioning of all existing KEPs in Europe, as well as their opportunities and challenges. Following a comparative analysis, results were synthesised and interpreted by the same experts. Results: The practices, opportunities and challenges reported by 17 European countries reveal that some of the 10 operating programmes are mature, while others are in earlier stages of development. Over 1300 transplants were performed through existing KEPs up to the end of 2016, providing approximately 8% of their countries’ living kidney donations in 2015. All countries report challenges to either initiating KEPs or increasing volumes. Some challenges are shared, whilst others differ because of differences in context (eg, country size, effectiveness of deceased donor programme) and ethical and legal considerations (eg, regarding living donation as such, nonrelated donors, and altruistic donation). Transnational initiatives have started in Central Europe, Scandinavia, and Southern Europe. Conclusions: Exchange of best practices and shared advancement of national programmes to address existing challenges, aided by transnational exchanges, may substantially improve access to the most (cost) effective treatment for the increasing number of patients suffering from kidney disease.

Item Type:Articles
Additional Information:This article is based upon work from COST Action ENCKEP (CA15210), supported by COST (European Cooperation in Science and Technology); see COST financed our meetings (i.e., the travel and accommodation costs of the participants), but it provided no other personal financial support to the authors. Personal acknowledgements: PB is supported by the Hungarian Academy of Sciences under research grants no. LP2016-3/2017 and KEP-6/2017 and by the Hungarian Scientific Research Fund (OTKA) Grant No. K129086. DM is supported by grant EP/P028306/1 from the Engineering and Physical Sciences Research Council. TA is funded by the Jan Wallander and Tom Hedelius Foundation (P2016-0126:1) and the Ragnar Söderberg Foundation (E8/13).
Glasgow Author(s) Enlighten ID:Biro, Dr Peter and Manlove, Professor David and Cechlarova, Professor Katarina
Authors: Biró, P., Haase-Kromwijk, B., Andersson, T., Ásgeirsson, E. I., Baltesová, T., Boletis, I., Bolotinha, C., Bond, G., Böhmig, G., Burnapp, L., Cechlárová, K., Di Ciaccio, P., Fronek, J., Hadaya, K., Hemke, A., Jacquelinet, C., Johnson, R., Kieszek, R., Kuypers, D., Leishman, R., Macher, M.-A., Manlove, D., Menoudakou, G., Salonen, M., Smeulders, B., Sparacino, V., Spieksma, F., Muñoz, M. d. l. O. V., Wilson, N., and vd Klundert, J.
College/School:College of Science and Engineering > School of Computing Science
Journal Name:Transplantation
Publisher:Lippincott, Williams and Wilkins
ISSN (Online):1534-6080
Published Online:21 September 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Transplantation 103(7): 1514-1522
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
3046940European Network for Collaboration on Kidney Exchange ProgrammesDavid ManloveEuropean Commission (EC)N/AComputing Science
3008080IP-MATCH: Integer Programming for Large and Complex Matching ProblemsDavid ManloveEngineering and Physical Sciences Research Council (EPSRC)EP/P028306/1Computing Science