Sugrue, E. , Hartley, C. J., Scott, C. and Jackson, C. J. (2016) The evolution of new catalytic mechanisms for xenobiotic hydrolysis in bacterial metalloenzymes. Australian Journal of Chemistry, 69(12), pp. 1383-1395. (doi: 10.1071/CH16426)
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Abstract
An increasing number of bacterial metalloenzymes have been shown to catalyse the breakdown of xenobiotics in the environment, while others exhibit a variety of promiscuous xenobiotic-degrading activities. Several different evolutionary processes have allowed these enzymes to gain or enhance xenobiotic-degrading activity. In this review, we have surveyed the range of xenobiotic-degrading metalloenzymes, and discuss the molecular and catalytic basis for the development of new activities. We also highlight how our increased understanding of the natural evolution of xenobiotic-degrading metalloenzymes can be been applied to laboratory enzyme design.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sugrue, Dr Elena |
| Authors: | Sugrue, E., Hartley, C. J., Scott, C., and Jackson, C. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Australian Journal of Chemistry |
| Publisher: | CSIRO Publishing |
| ISSN: | 0004-9425 |
| ISSN (Online): | 1445-0038 |
| Published Online: | 23 September 2016 |
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