Chemotherapy accelerates the development of acquired immune responses to Schistosoma haematobium infection

Mutapi, F., Ndhlovu, P. D., Hagan, P., Spicer, J. T., Mduluza, T., Turner, C. M. R., Chandiwana, S. K. and Woolhouse, M. E.J. (1998) Chemotherapy accelerates the development of acquired immune responses to Schistosoma haematobium infection. Journal of Infectious Diseases, 178(1), pp. 289-293. (doi:10.1086/517456) (PMID:9652458)

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Abstract

Treatment of 41 Schistosoma haematobium-infected children, 5–16 years old, with the drug praziquantel induced a switch from a predominantly IgA-specific antibody response to a predominantly IgG1 response within 12 weeks. A cross-sectional survey suggests that the same switch occurs naturally, but over several years, as children age (n = 251). The switch may be driven by alterations in cytokine levels in response to the release of antigens by dead or damaged parasites. Adults are more resistant to schistosome infection than children, and the switch to an “adult” response suggests that praziquantel treatment may have an immunizing effect, with benefits extending beyond a transient reduction in levels of infection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hagan, Professor Paul and Scott, Dr Janet and Turner, Professor Charles
Authors: Mutapi, F., Ndhlovu, P. D., Hagan, P., Spicer, J. T., Mduluza, T., Turner, C. M. R., Chandiwana, S. K., and Woolhouse, M. E.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Infectious Diseases
Publisher:Infectious Diseases Society of America
ISSN:0022-1899
ISSN (Online):1537-6613

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