Surface-mediated supramolecular self-assembly of protein, peptide and nucleoside derivatives: from surface design to underlying mechanism and tailored functions

Yang, B., Adams, D. J. , Marlow, M. and Zelzer, M. (2018) Surface-mediated supramolecular self-assembly of protein, peptide and nucleoside derivatives: from surface design to underlying mechanism and tailored functions. Langmuir, 34, pp. 15109-15125. (doi: 10.1021/acs.langmuir.8b01165) (PMID:30032622)

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Abstract

Amongst the many parameters that have been explored to exercise control over self-assembly processes, the influence of surface properties on self-assembly has been recognized as important but has received considerably less attention than other factors. This is particularly true for biomolecule-derived self-assembling molecules such as protein, peptide or nucleobase derivatives. Due to their relevance for biomaterial and drug delivery applications, interest in these materials is increasing. As the formation of supramolecular structures from these biomolecule derivatives inevitably brings them into contact with surfaces of surrounding materials, understanding and control of the impact of the properties of these surfaces on the self-assembly process is important. In this review, we present an overview of the different surface parameters that have been used and studied for the direction of the self-assembly of protein, peptide and nucleoside-based molecules. The current mechanistic understanding of these processes will be discussed and potential applications of surface-mediated self-assembly will be outlined.

Item Type:Articles
Additional Information:This work was supported by the Leverhulme Trust (grant number RPG-2016-199) via a research project grant for M.Z., M.M., D.J.A., and B.Y. and the Engineering and Physical Sciences Research Council (grant number EP/L021978/1) via a fellowship for D.J.A.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: Yang, B., Adams, D. J., Marlow, M., and Zelzer, M.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Langmuir
Publisher:American Chemical Society
ISSN:0743-7463
ISSN (Online):1520-5827
Published Online:21 July 2018
Copyright Holders:Copyright © 2018 The American Chemical Society
First Published:First published in Langmuir 34:15109-15125
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
768041Multicomponent Supramolecular HydrogelsDave AdamsEngineering and Physical Sciences Research Council (EPSRC)EP/L021978/2SCHOOL OF CHEMISTRY