Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study

Marshall, I. et al. (2018) Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study. Journal of Neurology, 265(8), pp. 1795-1802. (doi: 10.1007/s00415-018-8903-y) (PMID:29846780) (PMCID:PMC6060762)

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Abstract

AbstractProton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal-appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is not consistent with the usual assumption of ‘chronic’ lesions in SPMS, and may represent a target for repair therapies.

Item Type:Articles
Additional Information:. This independent research is awarded by the Efficacy and Mechanism Evaluation Programme (EME: reference 11/30/11), funded by the Medical Research Council (MRC) and the Multiple Sclerosis Society (MS Society), and managed by the National Institute for Health Research (NIHR) on behalf of the MRC-NIHR partnership.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dickie, Dr David Alexander
Authors: Marshall, I., Thrippleton, M. J., Bastin, M. E., Mollison, D., Dickie, D. A., Chappell, F. M., Semple, S. I.K., Cooper, A., Pavitt, S., Giovannoni, G., Wheeler-Kingshott, C. A.M. G., Solanky, B. S., Weir, C. J., Stallard, N., Hawkins, C., Sharrack, B., Chataway, J., Connick, P., and Chandran, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Neurology
Publisher:Springer
ISSN:0340-5354
ISSN (Online):1432-1459
Published Online:30 May 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Neurology 265(8): 1795-1802
Publisher Policy:Reproduced under a Creative Commons License

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