Shared genetic contribution of type 2 diabetes and cardiovascular disease: Implications for prognosis and treatment

Strawbridge, R. J. and van Zuydam, N. R. (2018) Shared genetic contribution of type 2 diabetes and cardiovascular disease: Implications for prognosis and treatment. Current Diabetes Reports, 18(8), 59. (doi:10.1007/s11892-018-1021-5) (PMID:29938349) (PMCID:PMC6015804)

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Abstract

Purpose of Review: The increased cardiovascular disease (CVD) risk in subjects with type 2 diabetes (T2D) is well established. This review collates the available evidence and assesses the shared genetic background between T2D and CVD: the causal contribution of common risk factors to T2D and CVD and how genetics can be used to improve drug development and clinical outcomes. Recent Findings: Large-scale genome-wide association studies (GWAS) of T2D and CVD support a shared genetic background but minimal individual locus overlap. Summary: Mendelian randomisation (MR) analyses show that T2D is causal for CVD, but GWAS of CVD, T2D and their common risk factors provided limited evidence for individual locus overlap. Distinct but functionally related pathways were enriched for CVD and T2D genetic associations reflecting the lack of locus overlap and providing some explanation for the variable associations of common risk factors with CVD and T2D from MR analyses.

Item Type:Articles
Keywords:Genetics, type 2 diabetes, coronary artery disease, ischemic stroke, peripheral artery disease, risk factors, genetics; mendelian randomisation
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Strawbridge, Dr Rona
Authors: Strawbridge, R. J., and van Zuydam, N. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Current Diabetes Reports
Publisher:Springer
ISSN:1534-4827
ISSN (Online):1539-0829
Published Online:25 June 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Current Diabetes Reports 18(8):59
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
3021310Understanding the excess risk of cardiometabolic disease in individuals with serious mental illnessJill PellMedical Research Council (MRC)MR/S003061/1HW - Public Health