Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes

Nelson, S., Freeman, D.J. , Sattar, N. and Lindsay, R.S. (2008) Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes. Diabetes Care, 31(6), pp. 1123-1125. (doi:10.2337/dc07-2195)

Full text not currently available from Enlighten.

Abstract

OBJECTIVE—To assess the association of fetal hormones with placental growth and fetal weight–to–placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes. RESEARCH DESIGN AND METHODS—We conducted a prospective study using umbilical venous blood samples taken at birth from 122 offspring of mothers with type 1 diabetes (OT1D) and 46 control subjects. RESULTS—Placental weight (P = 0.009) and gestation-adjusted birth weight (P < 0.001) were increased in OT1D, but FPI was unaltered (P = 0.33). Placental weight correlated with birth weight (P < 0.001) and cord leptin (P < 0.001) in control subjects and OT1D, with further relationships with cord insulin, IGF-1, IGF-binding protein-3 (IGFBP-3), and triceps and subscapular thickness in OT1D. FPI was associated with adiponectin in both groups, even after adjustment for confounders. CONCLUSIONS—Placental and fetal growth show a parallel increase in mothers with type 1 diabetes. The possible role of adiponectin in matching of fetal and placental growth merits further study.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lindsay, Dr Robert and Freeman, Dr Dilys and Nelson, Professor Scott and Sattar, Professor Naveed
Authors: Nelson, S., Freeman, D.J., Sattar, N., and Lindsay, R.S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Diabetes Care
Publisher:American Diabetes Association
ISSN:1935-5548
ISSN (Online):0149-5992

University Staff: Request a correction | Enlighten Editors: Update this record