Differential binding patterns of anti-sulfatide antibodies to glial membranes

Meehan, G. R. , McGonigal, R. , Cunningham, M. E. , Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D. and Willison, H. J. (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)

Abstract

Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patterns found in neuropathy patients. We sought to address this issue by generating and characterising a panel of new anti-sulfatide monoclonal antibodies. These antibodies have sulfatide reactivity distinct from existing antibodies in assays and in binding to peripheral nerve tissues and can be used to provide insights into the pathophysiological roles of anti-sulfatide antibodies in demyelinating neuropathies.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Halstead, Dr Susan and Barrie, Mrs Jennifer and Gourlay, Mrs Dawn and Willison, Professor Hugh and Wang, Dr Yuzhong and Cunningham, Dr Madeleine and McGonigal, Dr Rhona and Yao, Dr Denggao and Meehan, Dr Gavin
• Authors: Meehan, G. R., McGonigal, R., Cunningham, M. E., Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D., and Willison, H. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Journal of Neuroimmunology
• Publisher: Elsevier
• ISSN: 0165-5728
• ISSN (Online): 1872-8421
• Published Online: 09 July 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Journal of Neuroimmunology 323: 28-35
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
72255	1	Pathophysiological factors in the diagnosis and treatment of the Guillain-Barre syndromes	Hugh Willison	Wellcome Trust (WELLCOTR)	202789/Z/16/Z	III -IMMUNOLOGY
54403	1	The structural and functional diversity of anti-glycolipid antibody repertoires and their nerve binding domains in human autoimmune neuropathy	Hugh Willison	Wellcome Trust (WELLCOTR)	092805/Z/10/Z	III -IMMUNOLOGY