Differential binding patterns of anti-sulfatide antibodies to glial membranes

Meehan, G. R. , McGonigal, R., Cunningham, M. E. , Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D. and Willison, H. J. (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)

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Abstract

Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patterns found in neuropathy patients. We sought to address this issue by generating and characterising a panel of new anti-sulfatide monoclonal antibodies. These antibodies have sulfatide reactivity distinct from existing antibodies in assays and in binding to peripheral nerve tissues and can be used to provide insights into the pathophysiological roles of anti-sulfatide antibodies in demyelinating neuropathies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Halstead, Dr Susan and Barrie, Mrs Jennifer and Yao, Dr Denggao and Gourlay, Mrs Dawn and Willison, Professor Hugh and Wang, Dr Yuzhong and Cunningham, Dr Madeleine and McGonigal, Dr Rhona and Meehan, Dr Gavin
Authors: Meehan, G. R., McGonigal, R., Cunningham, M. E., Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D., and Willison, H. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Neuroimmunology
Publisher:Elsevier
ISSN:0165-5728
ISSN (Online):1872-8421
Published Online:09 July 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Neuroimmunology 323: 28-35
Publisher Policy:Reproduced under a Creative Commons License

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