Malik, N. , Sansom, O. J. and Michie, A. M. (2018) The role of mTOR-mediated signals during haemopoiesis and lineage commitment. Biochemical Society Transactions, 46(5), pp. 1313-1324. (doi: 10.1042/BST20180141) (PMID:30154096) (PMCID:PMC6195642)
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Abstract
The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in the regulation of an array of cellular functions including protein and lipid synthesis, proliferation, cell size and survival. Here, we describe the role of mTOR during haemopoiesis within the context of mTORC1 and mTORC2, the distinct complexes in which it functions. The use of conditional transgenic mouse models specifically targeting individual mTOR signalling components, together with selective inhibitors, have generated a significant body of research emphasising the critical roles played by mTOR, and individual mTOR complexes, in haemopoietic lineage commitment and development. This review will describe the profound role of mTOR in embryogenesis and haemopoiesis, underscoring the importance of mTORC1 at the early stages of haemopoietic cell development, through modulation of stem cell potentiation and self-renewal, and erythroid and B cell lineage commitment. Furthermore, the relatively discrete role of mTORC2 in haemopoiesis will be explored during T cell development and B cell maturation. Collectively, this review aims to highlight the functional diversity of mTOR signalling and underline the importance of this pathway in haemopoiesis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Malik, Miss Natasha and Michie, Professor Alison and Sansom, Professor Owen |
| Authors: | Malik, N., Sansom, O. J., and Michie, A. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Biochemical Society Transactions |
| Publisher: | Portland Press |
| ISSN: | 0300-5127 |
| ISSN (Online): | 1470-8752 |
| Published Online: | 28 August 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Biochemical Society Transactions 46(5): 1313-1324 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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