Antibacterial surface modification of titanium implants in orthopaedics

Orapiriyakul, W., Young, P. S., Damiati, L. and Tsimbouri, P. M. (2018) Antibacterial surface modification of titanium implants in orthopaedics. Journal of Tissue Engineering, 9, pp. 1-16. (doi: 10.1177/2041731418789838) (PMID:30083308) (PMCID:PMC6071164)

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Abstract

The use of biomaterials in orthopaedics for joint replacement, fracture healing and bone regeneration is a rapidly expanding field. Infection of these biomaterials is a major healthcare burden, leading to significant morbidity and mortality. Furthermore, the cost to healthcare systems is increasing dramatically. With advances in implant design and production, research has predominately focussed on osseointegration; however, modification of implant material, surface topography and chemistry can also provide antibacterial activity. With the increasing burden of infection, it is vitally important that we consider the bacterial interaction with the biomaterial and the host when designing and manufacturing future implants. During this review, we will elucidate the interaction between patient, biomaterial surface and bacteria. We aim to review current and developing surface modifications with a view towards antibacterial orthopaedic implants for clinical applications.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Orapiriyakul, Wich and Tsimbouri, Dr Monica and Young, Dr Peter and Damiati, Laila
Authors: Orapiriyakul, W., Young, P. S., Damiati, L., and Tsimbouri, P. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Journal of Tissue Engineering
Publisher:SAGE Publications
ISSN:2041-7314
ISSN (Online):2041-7314
Published Online:25 July 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Tissue Engineering 9: 1-16
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
615571Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implantsMatthew DalbyEngineering and Physical Sciences Research Council (EPSRC)EP/K034898/1RI MOLECULAR CELL & SYSTEMS BIOLOGY