In-vivo evaluation of microultrasound and thermometric capsule endoscopes

Lay, H. S. et al. (2019) In-vivo evaluation of microultrasound and thermometric capsule endoscopes. IEEE Transactions on Biomedical Engineering, 66(3), pp. 632-639. (doi:10.1109/TBME.2018.2852715) (PMID:29993482)

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Abstract

Clinical endoscopy and colonoscopy are commonly used to investigate and diagnose disorders in the upper gastrointestinal tract and colon respectively. However, examination of the anatomically remote small bowel with conventional endoscopy is challenging. This and advances in miniaturization led to the development of video capsule endoscopy (VCE) to allow small bowel examination in a noninvasive manner. Available since 2001, current capsule endoscopes are limited to viewing the mucosal surface only due to their reliance on optical imaging. To overcome this limitation with submucosal imaging, work is under way to implement microultrasound (μUS) imaging in the same form as VCE devices. This paper describes two prototype capsules, termed Sonocap and Thermocap, which were developed respectively to assess the quality of μUS imaging and the maximum power consumption that can be tolerated for such a system. The capsules were tested in vivo in the oesophagus and small bowel of porcine models. Results are presented in the form of μUS B-scans as well as safe temperature readings observed up to 100 mW in both biological regions. These results demonstrate that acoustic coupling and μUS imaging can be achieved in vivo in the lumen of the bowel and the maximum power consumption that is possible for miniature μUS systems.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Turcanu, Mihnea and Cochran, Professor Alexander and Qiu, Dr Yongqiang and Connor, Mr Ciaran and Lay, Dr Holly and McPhillips, Miss Rachael
Authors: Lay, H. S., Cummins, G., Cox, B. F., Qiu, Y., Turcanu, M. V., McPhillips, R., Connor, C., Gregson, R., Clutton, E., Desmulliez, M. P.Y., and Cochran, S.
College/School:College of Science and Engineering
College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:IEEE Transactions on Biomedical Engineering
Publisher:Institute of Electrical and Electronics Engineers
ISSN:0018-9294
ISSN (Online):1558-2531
Published Online:05 July 2018
Copyright Holders:Copyright © 2018 IEEE
First Published:First published in IEEE Transactions on Biomedical Engineering 66(3):632-639
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
748241Sonopill: minimally invasive gastrointestinal diagnosis and therapyAlexander CochranEngineering and Physical Sciences Research Council (EPSRC)EP/K034537/2ENG - ENGINEERING SYSTEMS POWER & ENERGY