Damiati, L., Eales, M. G., Nobbs, A. H., Su, B., Tsimbouri, P. , Salmeron-Sanchez, M. and Dalby, M. J. (2018) Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants. Journal of Tissue Engineering, 9, pp. 1-16. (doi: 10.1177/2041731418790694) (PMID:30116518)
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Abstract
Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography modification and biological/non-biological coatings have been integrated into orthopaedic/dental implants in order to mimic the surrounding biological environment as well as reduce the inflammation/infection that may occur. In this review, we summarize the impact of various Ti coatings on cell behaviour both in vivo and in vitro. First, we focus on the Ti surface properties and their effects on osteogenesis and then on bacterial adhesion and viability. We conclude from the current literature that surface modification of Ti implants can be generated that offer both osteoinductive and antimicrobial properties.
Item Type: | Articles |
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Additional Information: | This study was also supported by a studentship to L.D. from University of Jeddah, Jeddah, Saudi Arabia. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Tsimbouri, Dr Monica and Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Damiati, Laila |
Authors: | Damiati, L., Eales, M. G., Nobbs, A. H., Su, B., Tsimbouri, P., Salmeron-Sanchez, M., and Dalby, M. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering > Biomedical Engineering |
Journal Name: | Journal of Tissue Engineering |
Publisher: | SAGE |
ISSN: | 2041-7314 |
ISSN (Online): | 2041-7314 |
Published Online: | 02 August 2018 |
Copyright Holders: | Copyright © 2018 The Authors |
First Published: | First published in Journal of Tissue Engineering 9:1-16 |
Publisher Policy: | Reproduced under a Creative Commons License |
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