Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants

Damiati, L., Eales, M. G., Nobbs, A. H., Su, B., Tsimbouri, P. , Salmeron-Sanchez, M. and Dalby, M. J. (2018) Impact of surface topography and coating on osteogenesis and bacterial attachment on titanium implants. Journal of Tissue Engineering, 9, pp. 1-16. (doi:10.1177/2041731418790694) (PMID:30116518)

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Abstract

Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography modification and biological/non-biological coatings have been integrated into orthopaedic/dental implants in order to mimic the surrounding biological environment as well as reduce the inflammation/infection that may occur. In this review, we summarize the impact of various Ti coatings on cell behaviour both in vivo and in vitro. First, we focus on the Ti surface properties and their effects on osteogenesis and then on bacterial adhesion and viability. We conclude from the current literature that surface modification of Ti implants can be generated that offer both osteoinductive and antimicrobial properties.

Item Type:Articles
Additional Information:This study was also supported by a studentship to L.D. from University of Jeddah, Jeddah, Saudi Arabia.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tsimbouri, Dr Penelope and Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Damiati, Laila
Authors: Damiati, L., Eales, M. G., Nobbs, A. H., Su, B., Tsimbouri, P., Salmeron-Sanchez, M., and Dalby, M. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Journal of Tissue Engineering
Publisher:SAGE
ISSN:2041-7314
ISSN (Online):2041-7314
Published Online:02 August 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Tissue Engineering 9:1-16
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
615571Multiscale topographical modulation of cells and bacteria for next generation orthopaedic implantsMatthew DalbyEngineering and Physical Sciences Research Council (EPSRC)EP/K034898/1RI MOLECULAR CELL & SYSTEMS BIOLOGY