Stott, D.I., Hassman, R., Neilson, L., and McGregor, A.M. (1988) Isoelectric focusing spectrotypes of anti-thyroglobulin autoantibodies in autoimmune thyroiditis: a PVG rat model. Clinical and Experimental Immunology, 73 (2). pp. 269-275. ISSN 0009-9104
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We have studied the isoelectric focusing (IEF) spectrotypes of autoantibodies against thyroglobulin in two rat models of Hashimoto's thyroiditis: (1) AUG strain rats immunized with autologous thyroglobulin in Freund's complete adjuvant; (2) PVG/c strain rats which have been thymectomized and sublethally irradiated. The IEF spectrotypes revealed differences between the two models. The anti-thyroglobulin response in immunized AUG rats is mainly oligoclonal or polyclonal, often with dominant clones in the spectrotype, similar to about 90% of Hashimoto's patients, whereas the response in the PVG/c rat is highly restricted. There were pronounced changes in spectrotype with time in the PVG/c, but not AUG, rats with considerable variation in the lifespan of individual clones. The maximum lifespan of an anti-self secreting B-cell clone in the PVG/c rat, determined by persistence of its clonotype, was at least 16 weeks.
|Glasgow Author(s) Enlighten ID:||Stott, Prof David|
|Authors:||Stott, D.I., Hassman, R., Neilson, L., and McGregor, A.M.|
|College/School:||College of Medical Veterinary and Life Sciences|
|Journal Name:||Clinical and Experimental Immunology|
|Publisher:||Wiley-Blackwell Publishing Ltd.|