Stott, D.I., Hassman, R., Neilson, L. and McGregor, A.M. (1988) Isoelectric focusing spectrotypes of anti-thyroglobulin autoantibodies in autoimmune thyroiditis: a PVG rat model. Clinical and Experimental Immunology, 73(2), pp. 269-275.
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Abstract
We have studied the isoelectric focusing (IEF) spectrotypes of autoantibodies against thyroglobulin in two rat models of Hashimoto's thyroiditis: (1) AUG strain rats immunized with autologous thyroglobulin in Freund's complete adjuvant; (2) PVG/c strain rats which have been thymectomized and sublethally irradiated. The IEF spectrotypes revealed differences between the two models. The anti-thyroglobulin response in immunized AUG rats is mainly oligoclonal or polyclonal, often with dominant clones in the spectrotype, similar to about 90% of Hashimoto's patients, whereas the response in the PVG/c rat is highly restricted. There were pronounced changes in spectrotype with time in the PVG/c, but not AUG, rats with considerable variation in the lifespan of individual clones. The maximum lifespan of an anti-self secreting B-cell clone in the PVG/c rat, determined by persistence of its clonotype, was at least 16 weeks.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Stott I, Professor David |
| Authors: | Stott, D.I., Hassman, R., Neilson, L., and McGregor, A.M. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Clinical and Experimental Immunology |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 0009-9104 |
| ISSN (Online): | 1365-2249 |
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