Anti-ganglioside antibodies in peripheral nerve pathology

Willison, H. J. (2018) Anti-ganglioside antibodies in peripheral nerve pathology. In: Sonnino, S. and Prinetti, A. (eds.) Gangliosides: Methods and Protocols. Series: Methods in molecular biology (1804). Humana Press: New York, NY, pp. 173-188. ISBN 9781493985517 (doi: 10.1007/978-1-4939-8552-4_7)

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Anti-ganglioside antibodies are principally associated with autoimmune peripheral neuropathies. In these disorders, immune attack is inadvertently directed at peripheral nerve by autoantibodies that target glycan structures borne by glycolipids, particularly gangliosides concentrated in nerve myelin and axons. The most thoroughly studied disorder is the acute paralytic disease, Guillain-Barré syndrome (GBS) in which IgG autoantibodies against gangliosides arise following acute infections, notably Campylobacter jejuni enteritis. Additionally, chronic autoimmune neuropathies are associated with IgM antibodies directed against many glycolipids including gangliosides. This introductory chapter briefly summarizes the immunological and pathological features of these disorders, focusing on the methodological development of antibody measurement and of animal models.

Item Type:Book Sections
Keywords:Animal models, autoantibody, autoimmunity, gangliosides, glycolipids, neuropathy, peripheral nerve.
Glasgow Author(s) Enlighten ID:Willison, Professor Hugh
Authors: Willison, H. J.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Publisher:Humana Press
Published Online:21 June 2018

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