Utilising proteomics to understand and define hypertension: where are we and where do we go?

Delles, C. , Carrick, E., Graham, D. and Nicklin, S. A. (2018) Utilising proteomics to understand and define hypertension: where are we and where do we go? Expert Review of Proteomics, 15(7), pp. 581-592. (doi: 10.1080/14789450.2018.1493927) (PMID:29999442) (PMCID:PMC6092739)

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Introduction: Hypertension is a complex and multifactorial cardiovascular disorder. With different mechanisms contributing to a different extent to an individual’s blood pressure the discovery of novel pathogenetic principles of hypertension is challenging. However, there is an urgent and unmet clinical need to improve prevention, detection and therapy of hypertension in order to reduce the global burden associated with hypertension-related cardiovascular diseases. Areas covered: Proteomic techniques have been applied in reductionist experimental models including angiotensin II infusion models in rodents and the spontaneously hypertensive rat in order to unravel mechanisms involved in blood pressure control and end organ damage. In humans proteomic studies mainly focus on prediction and detection of organ damage, particularly of heart failure and renal disease. Whilst there are only few proteomic studies specifically addressing human primary hypertension there are more data available in hypertensive disorders in pregnancy such as preeclampsia. We will review these studies and discuss implications of proteomics on precision medicine approaches. Expert commentary: Despite the potential of proteomic studies in hypertension there has been moderate progress in this area of research. Standardised large-scale studies are required in order to make best use of the potential that proteomics offers in hypertension and other cardiovascular diseases.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Graham, Dr Delyth and Nicklin, Professor Stuart and Carrick, Dr Emma and Delles, Professor Christian
Authors: Delles, C., Carrick, E., Graham, D., and Nicklin, S. A.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Expert Review of Proteomics
Publisher:Taylor & Francis
ISSN (Online):1744-8387
Published Online:12 July 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Expert Review of Proteomics 15(7):581-592
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
649661Angiotensin-(1-7) and angiotensin-(1-9): assessment as therapeutic targets in acute vascular injury and remodelling.Stuart NicklinMedical Research Council (MRC)MR/L019108/1RI CARDIOVASCULAR & MEDICAL SCIENCES
3004890Cardiac gene therapy with angiotensin-(1-9): dissecting the underlying mechanism for preservation of cardiac function post-myocardial infarctionStuart NicklinBritish Heart Foundation (BHF)PG/17/17/32877CAMS - Cardiovascular Science