Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections?

Delaney, C., Kean, R., Short, B., Tumelty, M., McLean, W. , Nile, C. and Ramage, G. (2018) Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections? Current Clinical Microbiology Reports, 5(3), pp. 190-200. (doi: 10.1007/s40588-018-0100-3)

Abstract

Purpose of Review: Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings: There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary: Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ramage, Professor Gordon and Kean, Mr Ryan and Nile, Dr Christopher and Delaney, Mr Christopher and Mclean, Professor William and Tumelty, Dr Maria
• Authors: Delaney, C., Kean, R., Short, B., Tumelty, M., McLean, W., Nile, C., and Ramage, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Current Clinical Microbiology Reports
• Publisher: Springer
• ISSN: 2196-5471
• ISSN (Online): 2196-5471
• Published Online: 30 June 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Current Clinical Microbiology Reports 5(3): 190-200
• Publisher Policy: Reproduced under a Creative Commons License