Docherty, K. F. and McMurray, J. J.V. (2019) Angiotensin receptor-neprilysin inhibitors: a new paradigm in heart failure with reduced ejection fraction. International Journal of Cardiology, 281, pp. 179-185. (doi: 10.1016/j.ijcard.2018.05.124) (PMID:29891240)
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Abstract
Despite significant advances in the last 30 years in reducing morbidity and mortality from heart failure with reduced ejection fraction (HFrEF) with pharmacological and device-based therapies, patients remain at a high risk of adverse cardiovascular outcomes. Sacubitril/valsartan, a first-in-class angiotensin receptor-neprilysin inhibitors (ARNI), has been shown to reduce the risk of cardiovascular death or heart failure hospitalisation and improve symptoms in patients with chronic, ambulatory, symptomatic HFrEF in a large, phase 3, multicentre, international, randomised controlled trial, PARADIGM-HF, when compared to the gold-standard angiotensin converting enzyme inhibitor, enalapril. This article will review the development of sacubitril/valsartan, the evidence for its use and its current and future role in the management of HFrEF.
Item Type: | Articles |
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Keywords: | Angiotensin receptor-neprilysin inhibitor, heart failure, heart failure with reduced ejection fraction, natriuretic peptides, neprilysin, renin-angiotensin aldosterone system. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Docherty, Dr Kieran and McMurray, Professor John |
Authors: | Docherty, K. F., and McMurray, J. J.V. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | International Journal of Cardiology |
Publisher: | Elsevier |
ISSN: | 0167-5273 |
ISSN (Online): | 1874-1754 |
Published Online: | 02 June 2018 |
Copyright Holders: | Copyright © 2018 Elsevier B.V. |
First Published: | First published in International Journal of Cardiology 281: 179-185 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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