Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion

Martin, G. A. , Tsim, S., Kidd, A. C., Foster, J. E., McLoone, P. , Chalmers, A. and Blyth, K. G. (2018) Pre-EDIT: protocol for a randomised feasibility trial of elastance-directed intrapleural catheter or talc pleurodesis (EDIT) in malignant pleural effusion. BMJ Open Respiratory Research, 5(1), e000293. (doi: 10.1136/bmjresp-2018-000293) (PMID:29862030) (PMCID:PMC5976095)

Abstract

Introduction: Non-expansile lung (NEL) is a common cause of talc pleurodesis (TP) failure in malignant pleural effusion (MPE), but is often occult prior to drainage. Reliable detection of NEL would allow patients to be allocated between intrapleural catheter (IPC) and TP. High pleural elastance (PEL) has been associated with NEL in observational studies. Pre-EDIT is a randomised feasibility trial of elastance-directed IPC or TP (EDIT) management using a novel, purpose-built digital pleural manometer (Rocket Medical, UK). Methods and analysis: Consecutive patients with MPE without prior evidence of NEL or preference for IPC will be randomised 1:1 between EDIT management and standard care (an attempt at TP). The primary objective is to determine whether sufficient numbers of patients (defined as 30 within 12 months (or 15 over 6 months)) can be recruited and randomised to justify a subsequent phase III trial testing the efficacy of EDIT management. Secondary objectives include safety, technical feasibility and validation of study design elements, including the definition of PEL using 4D pleural MRI before and after fluid aspiration. EDIT involves PEL assessment during a large volume pleural fluid aspiration, followed by an attempt at TP or placement of an IPC within 24 hours. Patients will be allocated to IPC if the rolling average PEL sustained over at least 250 mL fluid aspirated (PEL250) is ≥ 14.5 cm H2O/L. Ethics and dissemination: Pre-EDIT was approved by the West of Scotland Regional Ethics Committee on 8 March 2017 (Ref: 17/WS/0042). Results will be presented at scientific meetings and published in peer-reviewed journals.

• Item Type: Articles
• Additional Information: This work was supported by Rocket Medical (UK) and the West of Scotland Lung Cancer Research Group (Award September 2015). KGB is part-funded by NHS Research Scotland.
• Keywords: Pleural disease.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McLoone, Mr Philip and Blyth, Professor Kevin and Martin, Geoffrey and Foster, Dr John and Tsim, Dr Selina and Chalmers, Professor Anthony and Kidd, Mr Andrew
• Authors: Martin, G. A., Tsim, S., Kidd, A. C., Foster, J. E., McLoone, P., Chalmers, A., and Blyth, K. G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: BMJ Open Respiratory Research
• Publisher: BMJ Publishing Group
• ISSN: 2052-4439
• ISSN (Online): 2052-4439
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in BMJ Open Respiratory Research 5(1):e000293
• Publisher Policy: Reproduced under a Creative Commons License