High sensitivity troponin T and incident heart failure in older men: British Regional Heart Study

Welsh, P. et al. (2019) High sensitivity troponin T and incident heart failure in older men: British Regional Heart Study. Journal of Cardiac Failure, (doi:10.1016/j.cardfail.2018.08.002) (PMID:30103019) (In Press)

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Abstract

Background: Few data compare cardiac troponin T (cTnT) and troponin I (cTnI) in a general population. We sought evaluate the distribution and association between cTnT, cTnI, and cardiovascular risk factors in a large general population cohort. Methods: High-sensitivity cTnT and cTnI were measured in serum from 19,501 individuals in the Generation Scotland Scottish Family Health Study. Associations with cardiovascular risk factors were compared using age and sex adjusted regression. Observed age- and sex- stratified 99th centiles were compared to 99th centiles for cTnT (men 15.5ng/L, women 9.0ng/L) and cTnI (men 34.2ng/L, women 15.6ng/L) used in clinical practice. Results: cTnT and cTnI concentrations were detectable in 53.3% and 74.8% of participants respectively and were modestly correlated in unadjusted analyses (R2=21.3%), and only weakly correlated after adjusting for age and sex (R2=9.5%). Cardiovascular risk factors were associated with both troponins, but in age and sex adjusted analyses cTnI was more strongly associated with age, male sex, BMI, and SBP (P<0.0001 for all versus cTnT). cTnT 57 was more strongly associated with diabetes (P<0.0001 versus cTnI). The observed 99th centiles were broadly consistent with recommended 99th centiles in younger men and women. After the age of 60 years, observed 99th centiles increased substantially for cTnT, and beyond 70 years of age, the 99th centiles approximately doubled for both troponins. Conclusions: In the general population, cTnT and cTnI concentrations are weakly correlated and are differentially associated with cardiovascular risk factors. 99th centiles currently in use are broadly appropriate for men and women up to but not beyond the age of 60 years.

Item Type:Articles
Status:In Press
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preiss, Dr David and McConnachie, Dr Alex and Boachie, Mr Charles and Padmanabhan, Professor Sandosh and Welsh, Dr Paul and Briggs, Professor Andrew and Woodward, Professor Mark and McAllister, Dr David and Sattar, Professor Naveed and Welsh, Dr Claire
Authors: Welsh, P., Preiss, D., Shah, A. S.V., McAllister, D., Briggs, A., Boachie, C., McConnachie, A., Hayward, C., Padmanabhan, S., Welsh, C., Woodward, M., Campbell, A., Porteous, D., Mills, N., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Journal of Cardiac Failure
Publisher:Elsevier
ISSN:1071-9164
ISSN (Online):1532-8414
Published Online:11 August 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Cardiac Failure 2018
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
612031Cardiac biomarkers and CVD risk screening: a cost-effective public health measure?Paul WelshBritish Heart Foundation (BHF)FS/12/62/29889RI CARDIOVASCULAR & MEDICAL SCIENCES