Central neuropathic pain in paraplegia alters movement related potentials

Vuckovic, A., Jarjees, M., Hasan, M. A., Miyakoshi, M. and Fraser, M. (2018) Central neuropathic pain in paraplegia alters movement related potentials. Clinical Neurophysiology, 129(8), pp. 1669-1679. (doi: 10.1016/j.clinph.2018.05.020) (PMID:29933240)

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Abstract

Objectives: Spinal Cord Injured (SCI) persons with and without Central Neuropathic Pain (CNP) show different oscillatory brain activities during imagination of movement. This study investigates whether they also show differences in movement related cortical potentials (MRCP). Methods: SCI paraplegic patients with no CNP (n = 8), with CNP in their lower limbs (n = 8), and healthy control subjects (n = 10) took part in the study. EEG clustering involved independent component analysis, equivalent current dipole fitting, and Measure Projection to define cortical domains that have functional modularity during the motor imagery task. Results: Three domains were identified: limbic system, sensory-motor cortex and visual cortex. The MRCP difference between the groups of SCI with and without CNP was reflected in a domain located in the limbic system, while the difference between SCI patients and control subjects was in the sensorimotor domain. Differences in MRCP morphology between patients and healthy controls were visible for both paralysed and non paralysed limbs. Conclusion: SCI but not CNP affects the movement preparation, and both SCI and CNP affect sensory processes. Significance: Rehabilitation strategies of SCI patients based on MRCP should take into account the presence of CNP.

Item Type:Articles
Additional Information:This work was also supported by a NED University of Pakistan PhD scholarship and a PhD Scholarships by the High Committee for Education Development, Iraq.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jarjees, Mohammed Sabah and Vuckovic, Dr Aleksandra
Authors: Vuckovic, A., Jarjees, M., Hasan, M. A., Miyakoshi, M., and Fraser, M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Clinical Neurophysiology
Publisher:Elsevier
ISSN:1388-2457
ISSN (Online):1872-8952
Published Online:15 June 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Clinical Neurophysiology 129(8):1669-1679
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
533931Neurofeedback for treatent of neuropathic pain in patients with spinal cord injuryAleksandra VuckovicMedical Research Council (MRC)G0902257ENG - BIOMEDICAL ENGINEERING