Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial

Gladden, N., McKeegan, D. , Viora, L. and Ellis, K. A. (2018) Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial. Veterinary Record, 183(13), 414. (doi:10.1136/vr.104913) (PMID:29960984)

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Abstract

Dystocia is considered painful and stressful for both the dam and the calf, although systematic evidence of this is limited. Few studies have investigated biochemical markers of stress and pain postpartum and whether any adverse effects are ameliorated by administration of analgesia. In this study, cow–calf pairs experiencing both mild to moderate farmer assistance and no assistance at parturition were randomly assigned to either treatment or placebo group in a two-by-two design (animals subject to veterinary intervention were excluded). The treatments were the NSAID ketoprofen or saline, administered within three hours of parturition. Blood samples taken in the immediate postpartum period, and at 24 hours, 48 hours and 7 days after parturition, were analysed for plasma concentrations of creatine kinase and cortisol (cows and calves) and plasma L-lactate and total protein concentration (calves). Stress biomarkers were highest in the immediate postpartum period and declined over time (P<0.05). Cow plasma cortisol was higher in animals experiencing assisted parturition in the immediate postpartum period (P=0.023); by 24 hours no difference was evident. Intervention with NSAID analgesia did not result in beneficial changes in stress biomarkers. Based on biomarkers alone, this suggests limited benefits of NSAID treatment in unassisted or mild to moderately assisted parturition.

Item Type:Articles
Additional Information:Funding was provided by Merial Animal Health, University of Glasgow James Herriot Fund and the James Houston Crawford Endowment Fund.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Viora, Dr Lorenzo and Ellis, Dr Kathryn and McKeegan, Dr Dorothy and Gladden, Nicola
Authors: Gladden, N., McKeegan, D., Viora, L., and Ellis, K. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Record
Publisher:BMJ Group
ISSN:0042-4900
ISSN (Online):2042-7670
Published Online:30 June 2018
Copyright Holders:Copyright © 2018 British Veterinary Association
First Published:First published in Veterinary Record 183(13): 414
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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