A comparative study of acute phase protein concentrations in historical and modern broiler breeding lines

O'Reilly, E.L., Bailey, R.A. and Eckersall, P.D. (2018) A comparative study of acute phase protein concentrations in historical and modern broiler breeding lines. Poultry Science, 97(11), pp. 3847-3853. (doi:10.3382/ps/pey272) (PMID:29982816) (PMCID:PMC6162364)

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Abstract

Acute-phase proteins (APP) are secreted from the liver as a result of inflammation or infection and are measurable in serum and plasma. To determine whether the constitutive APP serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP), ceruloplasmin (Cp), and ovotransferrin (Ovt) have changed as a result of selection for improved production and growth characteristics over the last 40 yr two historical broilers lines were compared to a modern line of the same lineage. Serum was harvested from blood samples taken from the 3 broiler lines on days 10, 17, and 20, and the APP concentrations were determined using immunoassay methods. Most of the significant changes observed were age related, with SAA and Cp having significantly lower concentrations at day 20 than days 10 and 17 in all lines. The only significant difference between lines was observed at day 20 on which both Cp (P = 0.01) and AGP (P = 0.03) were significantly higher in the modern line than the 90s line, though no significant differences were noted between the modern and 70s line. When evaluating the difference in APP concentrations between males (Cx) and females (Px) across all 3 lines, females had a higher SAA at day 17 and lower SAA at day 20, P = 0.0078 and 0.0327 respectively, and males had a significantly higher Ovt on days 17 and 20 (P = 0.0002 and P = 0.003 respectively). These results reveal that APP concentrations fluctuate over this early period of growth and that the changes in APP serum concentration appear uniform between 3 lines with very contrasting selection history, suggesting the improvements made in meat production efficiency since the 1970s have not affected the circulating concentrations of these constitutively expressed APP.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Eckersall, Professor Peter and O'Reilly, Dr Emily
Authors: O'Reilly, E.L., Bailey, R.A., and Eckersall, P.D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Poultry Science
Publisher:Oxford University Press
ISSN:0032-5791
ISSN (Online):1525-3171
Published Online:30 June 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Poultry Science 97(11): 3847-3853
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
542011Biomarkers of the innate immune response to disease in chickens: acute phase proteins and resistance to diseasePeter EckersallBiotechnology and Biological Sciences Research Council (BBSRC)BB/H016171/1III - PARASITOLOGY