Intestinal stem cell dynamics: a story of mice and humans

Hodder, M. C., Flanagan, D. J. and Sansom, O. J. (2018) Intestinal stem cell dynamics: a story of mice and humans. Cell Stem Cell, 22(6), pp. 785-787. (doi:10.1016/j.stem.2018.05.005) (PMID:29859166)

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Abstract

Stem cell dynamics define the probability of accumulating mutations within the intestinal epithelium. In this issue of Cell Stem Cell, Nicholson et al. (2018) report that human intestinal stem cell dynamics differ significantly from those of mice and establish that oncogenic mutations are more likely to expand; therefore, "normal" epithelium may carry multiple mutations.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sansom, Professor Owen and Hodder, Michael
Authors: Hodder, M. C., Flanagan, D. J., and Sansom, O. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cell Stem Cell
Publisher:Elsevier (Cell Press)
ISSN:1934-5909
ISSN (Online):1875-9777
Copyright Holders:Copyright © 2018 Elsevier Inc.
First Published:First published in Cell Stem Cell 22(6): 785-787
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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