Statin use is not associated with future long-term care admission - extended follow-up of two randomised controlled trials

Burton, J. K. , Papworth, R., Haig, C. , McCowan, C. , Ford, I. , Stott, D. J. and Quinn, T. J. (2018) Statin use is not associated with future long-term care admission - extended follow-up of two randomised controlled trials. Drugs and Aging, 35(7), pp. 657-663. (doi:10.1007/s40266-018-0560-4) (PMID:29916140)

Burton, J. K. , Papworth, R., Haig, C. , McCowan, C. , Ford, I. , Stott, D. J. and Quinn, T. J. (2018) Statin use is not associated with future long-term care admission - extended follow-up of two randomised controlled trials. Drugs and Aging, 35(7), pp. 657-663. (doi:10.1007/s40266-018-0560-4) (PMID:29916140)

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Abstract

Background: Statins have been associated with later life, long-term care admission in observational studies. However, by preventing vascular events, statins may also prevent or delay admission. We wished to determine statin and long-term care admission associations in a randomised controlled trial context, and describe associations between long-term care admission and other clinical and demographic factors. Methods: We used extended follow-up of two randomised trial populations, using national data to assign the long-term care admission outcome, and included individuals screened or recruited to two large randomised trials of pravastatin 40 mg daily—the West of Scotland Coronary Prevention Study (WOSCOPS) and the pravastatin in elderly individuals at risk of vascular disease (PROSPER) study. We described univariable and multivariable analyses of potential predictors of long-term care admission with corresponding survival curves of incident long-term care admission and analyses adjusted for competing risk. Results: In total 11,015 (10%) of the trial participants were admitted to long-term care. There was no difference between participants in the statin or placebo arms of either trial in regard to admissions to long-term care. On multivariable analyses, independent associations with incident long-term care admission in the PROSPER trial were age (hazard ratio [HR] 1.06 per year, 95% confidence interval [CI] 1.03–1.09) and male sex (HR 0.72, 95% CI 0.53–0.99). In the WOSCOPS, age (HR 1.12 per year, 95% CI 1.10–1.13) and increasing social deprivation (HR 1.05, 95% CI 1.03–1.08) were associated with incident long-term care admission. Conclusion: We did not demonstrate an association between historical statin use and future long-term care admission. The strongest associations with incident long-term care admission were non-modifiable factors of age, sex and socioeconomic deprivation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Quinn, Dr Terence and Mccowan, Professor Colin and Stott J, Professor David and Haig, Dr Caroline and Burton, Dr Jennifer and Ford, Professor Ian and Papworth, Dr Richard
Authors: Burton, J. K., Papworth, R., Haig, C., McCowan, C., Ford, I., Stott, D. J., and Quinn, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Drugs and Aging
Publisher:Adis
ISSN:1170-229X
ISSN (Online):1179-1969
Published Online:19 June 2018
Copyright Holders:Copyright © 2018 Springer International Publishing AG, part of Springer Nature
First Published:First published in Drugs and Aging 35(7): 657-663
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
687821Is statin use associated with care-home admission: Describing care-home admission as a novel study "outcome" using long term follow up of trial participants and screeneesTerence QuinnChief Scientist office (CSO)HICG/1/14RI CARDIOVASCULAR & MEDICAL SCIENCES