Biomechanical relevance of the microstructure in artery walls with a focus on passive and active components

Holzapfel, G. A. and Ogden, R. W. (2018) Biomechanical relevance of the microstructure in artery walls with a focus on passive and active components. American Journal of Physiology: Heart and Circulatory Physiology, 315(3), H540-H549. (doi:10.1152/ajpheart.00117.2018) (PMID:29799274)

[img]
Preview
Text
163410.pdf - Accepted Version

19MB

Abstract

The microstructure of arteries, consisting, in particular, of collagen, elastin and vascular smooth muscle cells, plays a very significant role in their biomechanical response during a cardiac cycle. In this paper we highlight the microstructure and the contributions of each of its components to the overall mechanical behavior. We also describe the changes of the microstructure which occur as a result of abdominal aortic aneurysms and disease such as atherosclerosis. We also focus on how the passive and active constituents are incorporated into a mathematical model without going into detail of the mathematical formulation. We conclude by mentioning open problems towards a better characterization of the biomechanical aspects of arteries that will be beneficial for a better understanding of cardiovascular pathophysiology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ogden, Professor Raymond and Holzapfel, Professor Gerhard
Authors: Holzapfel, G. A., and Ogden, R. W.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:American Journal of Physiology: Heart and Circulatory Physiology
Publisher:American Physiological Society
ISSN:0363-6135
ISSN (Online):1522-1539
Published Online:25 May 2018
Copyright Holders:Copyright © 2018 American Physiological Society
First Published:First published in American Journal of Physiology: Heart and Circulatory Physiology 315(3): H540-H549
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record