Osteoblast response to disordered nanotopography

Allan, C., Ker, A., Smith, C.-A. , Tsimbouri, P. , Borsoi, J., O'Neill, S., Gadegaard, N. , Dalby, M. J. and Meek, D. (2018) Osteoblast response to disordered nanotopography. Journal of Tissue Engineering, 9, pp. 1-7. (doi:10.1177/2041731418784098) (PMID:30034770) (PMCID:PMC6048666)

Allan, C., Ker, A., Smith, C.-A. , Tsimbouri, P. , Borsoi, J., O'Neill, S., Gadegaard, N. , Dalby, M. J. and Meek, D. (2018) Osteoblast response to disordered nanotopography. Journal of Tissue Engineering, 9, pp. 1-7. (doi:10.1177/2041731418784098) (PMID:30034770) (PMCID:PMC6048666)

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Abstract

The ability to influence stem cell differentiation is highly desirable as it would help us improve clinical outcomes for patients in various aspects. Many different techniques to achieve this have previously been investigated. This concise study, however, has focused on the topography on which cells grow. Current uncemented orthopaedic implants can fail if the implant fails to bind to the surrounding bone and, typically, forms a soft tissue interface which reduces direct bone contact. Here, we look at the effect of a previously reported nanotopography that utilises nanodisorder to influence mesenchymal stromal cell (as may be found in the bone marrow) differentiation towards bone and to also exert this effect on mature osteoblasts (as may be found in the bone). As topography is a physical technique, it can be envisaged for use in a range of materials such as polymers and metals used in the manufacture of orthopaedic implants.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tsimbouri, Dr Penelope and Meek, Professor Dominic and Gadegaard, Professor Nikolaj and Dalby, Professor Matthew and Smith, Mrs Carol-Anne
Authors: Allan, C., Ker, A., Smith, C.-A., Tsimbouri, P., Borsoi, J., O'Neill, S., Gadegaard, N., Dalby, M. J., and Meek, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Journal of Tissue Engineering
Publisher:SAGE
ISSN:2041-7314
ISSN (Online):2041-7314
Published Online:11 July 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Tissue Engineering 9:1-7
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
438161Stem Cell Differentiation & Genomic Processes in Response to Bioactive NanotopographyMatthew DalbyBiotechnology and Biological Sciences Research Council (BBSRC)BB/G008868/1RI MOLECULAR CELL & SYSTEMS BIOLOGY