Campbell, K. J. and Tait, S. W.J. (2018) Targeting BCL-2 regulated apoptosis in cancer. Open Biology, 8(5), 180002. (doi: 10.1098/rsob.180002) (PMID:29769323) (PMCID:PMC5990650)
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Abstract
The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death during development and maintains organismal health. When unbalanced, the BCL-2 family can act as a barrier to apoptosis and facilitate tumour development and resistance to cancer therapy. Here we discuss the BCL-2 family, their deregulation in cancer and recent pharmaceutical developments to target specific members of this family as cancer therapy.
| Item Type: | Articles |
|---|---|
| Additional Information: | Research in our laboratory is supported by Cancer Research UK, Breast Cancer Now and Tenovus Scotland. |
| Keywords: | BAX/BAK, BCL-2 family, apoptosis. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Campbell, Dr Kirsteen and Tait, Professor Stephen |
| Authors: | Campbell, K. J., and Tait, S. W.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Open Biology |
| Publisher: | The Royal Society Publishing |
| ISSN: | 2046-2441 |
| ISSN (Online): | 2046-2441 |
| Published Online: | 16 May 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Open Biology 8(5): 180002 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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