Simulation of melanoblast displacements reveals new features of developmental migration

Laurent, P., Petit, V., Aktary, Z., Gallagher, S., Tweedy, L., Machesky, L. and Larue, L. (2018) Simulation of melanoblast displacements reveals new features of developmental migration. Development, 145(12), dev160200. (doi: 10.1242/dev.160200) (PMID:29769218)

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Abstract

To distribute and establish the melanocyte lineage throughout the skin and other developing organs, melanoblasts undergo several rounds of proliferation, accompanied by migration through complex environments and differentiation. Melanoblast migration requires interaction with extracellular matrix of the epidermal basement membrane and with surrounding keratinocytes in the developing skin. Migration has been characterized by measuring speed, trajectory and directionality of movement, but there are many unanswered questions about what motivates and defines melanoblast migration. Here, we established a general mathematical model to simulate the movement of melanoblasts in the epidermis based on biological data, assumptions and hypotheses. Comparisons between experimental data and computer simulations reinforce some biological assumptions and suggest new ideas for how melanoblasts and keratinocytes might influence each other duyring development. For instance, it appears that melanoblasts instruct each other to allow a homogeneous distribution in the tissue and that keratinocytes may attract melanoblasts until one is stably attached to them. Our model reveals new features of how melanoblasts move, and in particular, suggest that melanoblasts leave a repulsive trail behind them as they move through the skin.

Item Type:Articles
Additional Information:This work was supported by the Ligue Contre le Cancer - comitéde l’Oise, INCa, ITMO Cancer, and is under the program ‘Investissements d’Avenir’ launched by the French Government and implemented by ANR Labex CelTisPhyBio (ANR-11-LBX0038 and ANR-10-IDEX-0001-02 PSL). L.M. is funded by a core grant from Cancer Research UK (A15673).
Keywords:Memory, migration, mouse, trajectories.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura
Authors: Laurent, P., Petit, V., Aktary, Z., Gallagher, S., Tweedy, L., Machesky, L., and Larue, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Development
Publisher:Company of Biologists
ISSN:0950-1991
ISSN (Online):1477-9129
Published Online:16 May 2018
Copyright Holders:Copyright © 2018 The Company of Biologists Ltd
First Published:First published in Development 145(12): dev160200
Publisher Policy:Reproduced under a Creative Commons License

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