Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating

Du, R. et al. (2018) Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating. NPG Asia Materials, 10, pp. 642-658. (doi:10.1038/s41427-018-0064-z)

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Abstract

In this study, we designed a novel drug-eluting coating for vascular implants consisting of a core coating of the anti-proliferative drug docetaxel (DTX) and a shell coating of the platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21. The core/shell structure was sprayed onto the surface of 316L stainless steel stents using a coaxial electrospray process with the aim of creating a coating that exhibited a differential release of the two drugs. The prepared stents displayed a uniform coating consisting of nano/micro particles. In vitro drug release experiments were performed, and we demonstrated that a biphasic mathematical model was capable of capturing the data, indicating that the release of the two drugs conformed to a diffusion-controlled release system. We demonstrated that our coating was capable of inhibiting the adhesion and activation of platelets, as well as the proliferation and migration of smooth muscle cells (SMCs), indicating its good biocompatibility and anti-proliferation qualities. In an in vivo porcine coronary artery model, the SZ-21/DTX drug-loaded hydrophobic core/hydrophilic shell particle coating stents were observed to promote re-endothelialization and inhibit neointimal hyperplasia. This core/shell particle-coated stent may serve as part of a new strategy for the differential release of different functional drugs to sequentially target thrombosis and in-stent restenosis during the vascular repair process and ensure rapid re-endothelialization in the field of cardiovascular disease.

Item Type:Articles
Additional Information:This study is supported by grants from the National Key Research and Development Program of China (2016YFC1102305), the National Natural Science Foundation of China (11332003), the Visiting Scholar Foundation of the Key Laboratory of Biorheological Science and Technology, Ministry of Education (CQKLBST-2016-003), the Fundamental Research Funds for the Central Universities (106112017CDJPT230001, 106112017CDJZRPY0202), and the National Key Technology R&D Program of China (2012BAI18B02) as well as the Science and Technology Commission of Yuzhong District in Chongqing (20150135).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mcginty, Dr Sean
Authors: Du, R., Wang, Y., Huang, Y., Zhao, Y., Du, D., Zhang, Y., Li, Z., McGinty, S., Pontrelli, G., Yin, T., and Wang, G.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:NPG Asia Materials
Publisher:Nature Publishing Group
ISSN:1884-4049
ISSN (Online):1884-4057
Published Online:19 July 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in NPG Asia Materials 10:642-658
Publisher Policy:Reproduced under a Creative Commons License

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