A rapid and robust diagnostic for liver fibrosis using a multichannel polymer sensor array

Peveler, W. J. , Landis, R. F., Yazdani, M., Day, J. W., Modi, R., Carmalt, C. J., Rosenberg, W. M. and Rotello, V. M. (2018) A rapid and robust diagnostic for liver fibrosis using a multichannel polymer sensor array. Advanced Materials, 30(28), 1800634. (doi:10.1002/adma.201800634) (PMID:29797373)

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Abstract

Liver disease is the fifth most common cause of premature death in the Western world, with the irreversible damage caused by fibrosis, and ultimately cirrhosis, a primary driver of mortality. Early detection of fibrosis would facilitate treatment of the underlying liver disease to limit progression. Unfortunately, most cases of liver disease are diagnosed late, with current strategies reliant on invasive biopsy or fragile lab-based antibody technologies. A robust, fully synthetic fluorescent-polymer sensor array is reported, which, rapidly (in 45 minutes), detects liver fibrosis from low-volume serum samples with clinically relevant specificity and accuracy, using an easily read- able diagnostic output. The simplicity, rapidity, and robustness of this method make it a promising platform for point-of-care diagnostics for detecting and monitoring liver disease.

Item Type:Articles
Additional Information:W.J.P. was supported by a Royal Society International Exchange Grant, and thanks the EPSRC for a Doctoral Prize Fellowship (EP/M506448/1) and the University of Glasgow for an LKAS Fellowship. W.M.R is an NIHR Senior Investigator and acknowledges the UCLH NIHR Biomedical Research Centre for funding. V.M.R. acknowledges the NIH (GM077173).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Peveler, Dr William
Authors: Peveler, W. J., Landis, R. F., Yazdani, M., Day, J. W., Modi, R., Carmalt, C. J., Rosenberg, W. M., and Rotello, V. M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Advanced Materials
Publisher:Wiley
ISSN:0935-9648
ISSN (Online):1521-4095
Published Online:24 May 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Advanced Materials 30(28): 1800634
Publisher Policy:Reproduced under a Creative Commons License

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