Biogelx: cell culture on self-assembling peptide gels

Harper, M. M., Connolly, M. L., Goldie, L., Irvine, E. J., Shaw, J. E., Jayawarna, V., Richardson, S. M., Dalby, M. J. , Lightbody, D. and Ulijn, R. V. (2018) Biogelx: cell culture on self-assembling peptide gels. In: Nilsson, B. L. and Doran, T. M. (eds.) Peptide Self-Assembly: Methods and Protocols. Series: Methods in molecular biology (1777). Humana Press: New York, NY, pp. 283-303. ISBN 9781493978090 (doi:10.1007/978-1-4939-7811-3_18)

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Abstract

Aromatic peptide amphiphiles can form self-supporting nanostructured hydrogels with tunable mechanical properties and chemical compositions. These hydrogels are increasingly applied in two-dimensional (2D) and three-dimensional (3D) cell culture, where there is a rapidly growing need to store, grow, proliferate, and manipulate naturally derived cells within a hydrated, 3D matrix. Biogelx Limited is a biomaterials company, created to commercialize these bio-inspired hydrogels to cell biologists for a range of cell culture applications. This chapter describes methods of various characterization and cell culture techniques specifically optimized for compatibility with Biogelx products.

Item Type:Book Sections
Keywords:Biomaterials, cell culture, hydrogels, self-assembly.
Status:Published
Glasgow Author(s) Enlighten ID:Jayawarna, Dr Vineetha and Dalby, Professor Matthew
Authors: Harper, M. M., Connolly, M. L., Goldie, L., Irvine, E. J., Shaw, J. E., Jayawarna, V., Richardson, S. M., Dalby, M. J., Lightbody, D., and Ulijn, R. V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering > Biomedical Engineering
Publisher:Humana Press
ISBN:9781493978090
Published Online:10 May 2018

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