Phenotypic screening of small molecules with antimalarial activity for three different parasitic life stages

Kato, N., March, S., Bhatia, S. N. and Marti, M. (2018) Phenotypic screening of small molecules with antimalarial activity for three different parasitic life stages. In: Wagner, B. (ed.) Phenotypic Screening: Methods and Protocols. Series: Methods in molecular biology (1787). Humana Press: New York, NY, pp. 41-52. ISBN 9781493978465 (doi: 10.1007/978-1-4939-7847-2_3)

Abstract

Malaria remains one of the deadliest infectious diseases globally. Available therapeutic agents are already limited in their efficacy, and drug resistance threatens to diminish further our ability to prevent and treat the disease. Despite a renewed effort to identify compounds with antimalarial activity, the drug discovery and development pipeline lacks target diversity and availability of compounds that target liver- and gametocyte-stage parasites. Phenotypic screens are a powerful and valuable tool for identifying new chemical compounds with antimalarial activity. This chapter highlights recent phenotypic screening methodologies for all three parasitic life stages.

• Item Type: Book Sections
• Keywords: Asexual blood-stage, gametocyte-stage, liver-stage, malaria, phenotypic screening, Plasmodium falciparum.
• Status: Published
• Glasgow Author(s) Enlighten ID: Marti, Professor Matthias
• Authors: Kato, N., March, S., Bhatia, S. N., and Marti, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Publisher: Humana Press
• ISBN: 9781493978465
• Published Online: 08 May 2018