Interindividual responses to different exercise stimuli among insulin-resistant women

Álvarez, C., Ramírez-Vélez, R., Ramírez-Campillo, R., Shigenori, I., Celis-Morales, C. , García-Hermoso, A., Rodriguez-Mañas, L., Lucia, A. and Izquierdo, M. (2018) Interindividual responses to different exercise stimuli among insulin-resistant women. Scandinavian Journal of Medicine and Science in Sports, 28(9), pp. 2052-2065. (doi:10.1111/sms.13213) (PMID:29749663)

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Abstract

We aimed to investigate which among 20 cardiometabolic and performance outcomes do and do not respond to high‐intensity interval training (HIT), resistance training (RT), or concurrent training (CT) in insulin‐resistant adult women. A secondary aim was to report the training‐induced changes and the prevalence of non‐responders. Forty‐five insulin‐resistant adult women were randomly assigned to one of the following 4 groups: HIT (39.2 ± 9.5 years [y]; body mass index [BMI], 29.3 ± 3.3; n = 14), RT (33.9 ± 9.3 y; BMI, 29.4 ± 5.5; n = 8), CT (43.3 ± 8.1 y; BMI, 29.1 ± 2.9; n = 10), and a control group (CG, 40.1 ± 11.4 y; BMI, 28.3 ± 3.5; n = 13). Nine body composition, 3 cardiovascular, 3 metabolic, and 5 performance outcomes were assessed at baseline and after 12 weeks of intervention. Considering all outcomes, the lowest number of total non‐responses for one or more variables was found in the RT group, followed by the CT and HIT groups. Individuals in the CG group were classified as non‐responders for almost all the variables. Moreover, there were several significant changes in body composition and metabolic parameters, including fasting glucose (HIT: −5.7, RT −5.1 mg/d), fasting insulin (HIT: −0.6, RT −0.6 μIU/mL), and HOMA‐IR (HIT: −0.3, RT −0.4), in addition to improvements in cardiovascular and performance parameters. Also, there were significant differences among groups in the prevalence of non‐responders for the variables where a non‐response was detected. Overall, the study suggests that independent of the mode of training including volume and frequency, RT has an important ability to reduce the prevalence of non- response to improve the 20 outcomes of health and performance in insulin- resistant adult women.

Item Type:Articles
Additional Information:The present research project was funded by grants from the Family Healthcare Center Tomas Rojas and with public funding from the Health Service of Los Ríos by the Health promotion program 2012 Mikel Izquierdo was funded by research grants RD12/043/0002 [Spanish Network on Aging and Frailty; (RETICEF)] (ISCIII, FEDER), CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), as well as by a research grant PI17/01814 of the Ministerio de Economía, Industria y Competitividad (ISCIII, FEDER).
Keywords:Physical therapy, sports therapy and rehabilitation, orthopedics and sports medicine.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos
Authors: Álvarez, C., Ramírez-Vélez, R., Ramírez-Campillo, R., Shigenori, I., Celis-Morales, C., García-Hermoso, A., Rodriguez-Mañas, L., Lucia, A., and Izquierdo, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Scandinavian Journal of Medicine and Science in Sports
Publisher:Wiley
ISSN:0905-7188
ISSN (Online):1600-0838
Published Online:11 May 2018

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