Uniparental inheritance of the mitochondrial gene cytochrome b in Plasmodium falciparum

Creasey, A. M., Ranford-Cartwright, L. C. , Moore, D. J., Williamson, D. H., Wilson, R. J.M., Walliker, D. and Carter, R. (1993) Uniparental inheritance of the mitochondrial gene cytochrome b in Plasmodium falciparum. Current Genetics, 23(4), pp. 360-364. (doi:10.1007/bf00310900) (PMID:8467535)

Full text not currently available from Enlighten.

Abstract

The inheritance of an extrachromosomal 6-kb element has been examined in the human malaria parasite Plasmodium falciparum. A single base pair difference in the cytochrome b gene from the 6-kb element of two different cloned lines of the parasite was identified, and used as a marker in a cross in the mosquito stage of the life cycle. Analysis of 59 individual hybrid oocysts resulting from this cross clearly demonstrated that inheritance of the cytochrome b gene was uniparental. This observation makes it possible to investigate the inheritance and evolution of cytoplasmic traits, including certain forms of drug resistance, in natural populations of this parasite.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ranford-Cartwright, Dr Lisa
Authors: Creasey, A. M., Ranford-Cartwright, L. C., Moore, D. J., Williamson, D. H., Wilson, R. J.M., Walliker, D., and Carter, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Current Genetics
Publisher:Springer
ISSN:0172-8083
ISSN (Online):1432-0983

University Staff: Request a correction | Enlighten Editors: Update this record