Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites

Babiker, H., Ranford-Cartwright, L. , Sultan, A., Satti, G. and Walliker, D. (1994) Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites. Transactions of the Royal Society of Tropical Medicine and Hygiene, 88(3), pp. 328-331. (doi:10.1016/0035-9203(94)90103-1) (PMID:7974680)

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Abstract

Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ranford-Cartwright, Dr Lisa
Authors: Babiker, H., Ranford-Cartwright, L., Sultan, A., Satti, G., and Walliker, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Transactions of the Royal Society of Tropical Medicine and Hygiene
Publisher:Elsevier
ISSN:0035-9203
ISSN (Online):1878-3503

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